Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment.

The long-term effect of AHSCT on MRI measures of MS evolution: A five-year follow-up study

MARROSU, MARIA GIOVANNA;LA NASA, GIORGIO;COCCO, ELEONORA;
2007

Abstract

Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment.
Atrophy; Autologous hematopoietic stem cell transplantation; Magnetic resonance imaging; Multiple sclerosis; Adult; Age of onset; Brain; Cyclophosphamide; Follow-up studies; Hematopoietic stem cell mobilization; Humans; Inflammation; Magnetic resonance imaging; Middle aged; Transplantation, autologous; Hematopoietic stem cell transplantation; Neurology (clinical)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11584/174621
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