Background This study aims to verify the feasibility of use of wearable accelerometers in an ambulatory environment to assess spatiotemporal parameters of gait in people with Multiple Sclerosis (pwMS), as well as the correlation of objective data with patient-reported outcomes. Methods One hundred and five pwMS (Expanded Disability Status Scale, EDSS in the range 0 - 6.5) classified in three sub-groups (EDSS 0–1.5, EDSS 2–4, EDSS 4.5–6.5) and 47 healthy controls (HC) participated in the study. All the subjects were evaluated with the timed 25-foot walking test (T25FW) while wearing a commercially available accelerometer. PwMS also rated the impact of the disease on their walking abilities using the 12-item MS walking scale (MSWS-12). Results All parameters objectively measured, except stride length, were significantly modified in pwMS with higher EDSS, with respect to HC and lower disability participants. Moderate to high correlations (r = 0.57 - 0.79) were observed between gait parameters and MSWS-12 for pwMS of higher EDSS. The correlation was found moderate correlated for the intermediate EDSS category (r = 0.42 - 0.62). Conclusion Wearable accelerometers are a useful tool for assessing gait performance for pwMS in a clinical setting, especially in cases of mild to moderate disability. Compared with other quantitative techniques, these devices allow patient testing under realistic conditions (i.e., fully dressed, with their usual shoes) using a simple procedure with immediate availability of data.

Clinical Assessment of Gait in Individuals with Multiple Sclerosis Using Wearable Inertial Sensors: Comparison with Patient-Based Measure

PAU, MASSIMILIANO;CORONA, FEDERICA;LEBAN, BRUNO;COGHE, GIANCARLO;LOREFICE, LORENA;MARROSU, MARIA GIOVANNA;COCCO, ELEONORA
2016

Abstract

Background This study aims to verify the feasibility of use of wearable accelerometers in an ambulatory environment to assess spatiotemporal parameters of gait in people with Multiple Sclerosis (pwMS), as well as the correlation of objective data with patient-reported outcomes. Methods One hundred and five pwMS (Expanded Disability Status Scale, EDSS in the range 0 - 6.5) classified in three sub-groups (EDSS 0–1.5, EDSS 2–4, EDSS 4.5–6.5) and 47 healthy controls (HC) participated in the study. All the subjects were evaluated with the timed 25-foot walking test (T25FW) while wearing a commercially available accelerometer. PwMS also rated the impact of the disease on their walking abilities using the 12-item MS walking scale (MSWS-12). Results All parameters objectively measured, except stride length, were significantly modified in pwMS with higher EDSS, with respect to HC and lower disability participants. Moderate to high correlations (r = 0.57 - 0.79) were observed between gait parameters and MSWS-12 for pwMS of higher EDSS. The correlation was found moderate correlated for the intermediate EDSS category (r = 0.42 - 0.62). Conclusion Wearable accelerometers are a useful tool for assessing gait performance for pwMS in a clinical setting, especially in cases of mild to moderate disability. Compared with other quantitative techniques, these devices allow patient testing under realistic conditions (i.e., fully dressed, with their usual shoes) using a simple procedure with immediate availability of data.
Multiple Sclerosis (MS), Gait, Expanded Disability Status Scale (EDSS), 12-item Multiple Sclerosis Walking Scale (MSWS-12), Timed 25-Foot Walk Test (T25FWT), Spatio-temporal parameters, Accelerometer
File in questo prodotto:
File Dimensione Formato  
MSARD_482_2016.pdf

Solo gestori archivio

Tipologia: versione editoriale
Dimensione 233.28 kB
Formato Adobe PDF
233.28 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11584/184426
Citazioni
  • ???jsp.display-item.citation.pmc??? 20
  • Scopus 45
  • ???jsp.display-item.citation.isi??? 41
social impact