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EnglishA new series of adamantanyl-1,3-thiazole and 1,3,4-oxadiazole derivatives (6a-l), bearing various aryl groups has been synthesized from adamantan-1-nitrile in four steps. All the compounds were evaluated, in vitro, for antiproliferative activity against a large panel of human tumor-derived cell lines. Compounds 6e exhibited activity against human splenic B-lymphoblastoid (WIL-2NS) and human acute B-lymphoblastic leukemia (CCRF-SB) cell lines with CC50 = 68 and 42 μM, respectively. Compound 61 showed activity against CCRF-SB cell lines with CC50 = 51 μM. All the other compounds were found inactive.
| Titolo: | Synthesis and in vitro antiproliferative activity of new adamantylthiazolyl-1,3,4-oxadiazoles |
| Autori: | |
| Data di pubblicazione: | 2009 |
| Rivista: | |
| Handle: | http://hdl.handle.net/11584/18782 |
| Tipologia: | 1.1 Articolo in rivista |
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|---|---|---|---|---|
| Zahid, La Colla.pdf | versione editoriale | Non specificato | Administrator Richiedi una copia |
http://hdl.handle.net/11584/18782
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