An asymmetric synthesis of α-aryl amino-β-nitro cyclohexanes has been achieved by means of a tandem aza-Michael addition-protonation reaction starting from 1-nitro cyclohexene and anilines. The transformation is proposed to proceed via a transient nitrile enolate which is subsequently stereoselectively protonated by an intramolecular transfer of the proton from nitrogen to the nitronate α-carbon.
Titolo: | Stereoselective aza-Michael addition of anilines to 1-nitro cyclohexene by intramolecular protonation | |
Autori: | ||
Data di pubblicazione: | 2015 | |
Rivista: | ||
Handle: | http://hdl.handle.net/11584/189004 | |
Tipologia: | 1.1 Articolo in rivista |
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