An asymmetric synthesis of α-aryl amino-β-nitro cyclohexanes has been achieved by means of a tandem aza-Michael addition-protonation reaction starting from 1-nitro cyclohexene and anilines. The transformation is proposed to proceed via a transient nitrile enolate which is subsequently stereoselectively protonated by an intramolecular transfer of the proton from nitrogen to the nitronate α-carbon.
|Titolo:||Stereoselective aza-Michael addition of anilines to 1-nitro cyclohexene by intramolecular protonation|
|Data di pubblicazione:||2015|
|Tipologia:||1.1 Articolo in rivista|