A simple and practical protocol for the construction of synthetically important quaternary α-benzyl- and α-allyl-α-methylamino cyclobutanones in good to high yield, via a sequential one-pot methylation/sigmatropic rearrangement, has been accomplished for the first time. The quaternary α-alkyl-α-amino cyclobutanones could be further manipulated, affording synthetically interesting scaffolds such as highly substituted tryptamines and cyclobuta-fused indolines.
|Titolo:||Synthesis of quaternary α-benzyl- and α-allyl-α-methylamino cyclobutanones|
|Data di pubblicazione:||2016|
|Tipologia:||1.1 Articolo in rivista|