The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions. Chemical evidences for an unusual competitive O2- vs. N1-alkylation of 3-substituted pyrimidines is presented.
Synthesis of carbocyclic pyrimidine nucleosides using the Mitsunobu reaction: O2- vs. N1-alkylation
DELOGU, GIOVANNA LUCIA;
2010
Abstract
The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions. Chemical evidences for an unusual competitive O2- vs. N1-alkylation of 3-substituted pyrimidines is presented.
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