Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method

Bhavsar, D; Trivedi, J; Parekh, S; Savant, M; Thakrar, S; Bavishi, A; Radadiya, A; Vala, H; Lunagariya, J; Parmar, M; Paresh, L; Loddo, Roberta; Shah, A.

doi:10.1016/j.bmcl.2011.03.105

A series of novel N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives has been synthesized. All the newly synthesized compounds were evaluated for their anti-HIV activity using MTT method. Most of these compounds showed moderate to potent activity against wild-type HIV-1 with an EC(50) ranging from >7 EC(50) [μg/ml] to <100 EC(50) [μg/ml]. Among them, N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide 6v was identified as the most promising compound (EC(50)=<7 μg/ml). Among all the compounds, three compounds 6m, 6v and 6u have been exhibits potent anti-HIV activity against MT-4 cells.

Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method / BHAVSAR D; TRIVEDI J; PAREKH S; SAVANT M; THAKRAR S; BAVISHI A; RADADIYA A; VALA H; LUNAGARIYA J; PARMAR M; PARESH L; LODDO R; SHAH A. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 21:11(2011), pp. 3443-3446.

Trovami (UniCASearch)

Titolo:	Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method
Autori:	BHAVSAR D TRIVEDI J PAREKH S SAVANT M THAKRAR S BAVISHI A RADADIYA A VALA H LUNAGARIYA J PARMAR M PARESH L LODDO, ROBERTA SHAH A. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2011
Rivista:	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Citazione:	Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method / BHAVSAR D; TRIVEDI J; PAREKH S; SAVANT M; THAKRAR S; BAVISHI A; RADADIYA A; VALA H; LUNAGARIYA J; PARMAR M; PARESH L; LODDO R; SHAH A. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 21:11(2011), pp. 3443-3446.
Handle:	http://hdl.handle.net/11584/204
Tipologia:	1.1 Articolo in rivista

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