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EnglishA series of novel N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives has been synthesized. All the newly synthesized compounds were evaluated for their anti-HIV activity using MTT method. Most of these compounds showed moderate to potent activity against wild-type HIV-1 with an EC(50) ranging from >7 EC(50) [μg/ml] to <100 EC(50) [μg/ml]. Among them, N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide 6v was identified as the most promising compound (EC(50)=<7 μg/ml). Among all the compounds, three compounds 6m, 6v and 6u have been exhibits potent anti-HIV activity against MT-4 cells.
| Titolo: | Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method |
| Autori: | |
| Data di pubblicazione: | 2011 |
| Rivista: | |
| Citazione: | Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method / BHAVSAR D; TRIVEDI J; PAREKH S; SAVANT M; THAKRAR S; BAVISHI A; RADADIYA A; VALA H; LUNAGARIYA J; PARMAR M; PARESH L; LODDO R; SHAH A. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 21:11(2011), pp. 3443-3446. |
| Handle: | http://hdl.handle.net/11584/204 |
| Tipologia: | 1.1 Articolo in rivista |
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