Cognitive and motor deficits have been proposed as markers of abnormal neurodevelopment in schizophrenia and have been associated with genetic liability. In a multicenter study involving 106 subjects, 56 with deficit schizophrenia and 50 with nondeficit schizophrenia, we tested the hypothesis that the catechol-O-methyltransferase (COMT) Val(158) Met polymorphism is associated with cognitive and motor deficits either in schizophrenia as a whole or in its deficit subtype. The COMT Val(158)Met polymorphism shared 6.6% of the executive/attention dysfunction variance in patients with schizophrenia and 15.6% of the motor impairment variance in patients with deficit schizophrenia. These results support the hypothesis that the COMT Val(158) Met polymorphism influences executive functions in schizophrenia and the neuromotor performance in the deficit subtype only

Catechol-O-methyltransferase Val(158)Met polymorphism in schizophrenia: associations with cognitive and motor impairment

SEVERINO, GIOVANNI;DEL ZOMPO, MARIA
2005

Abstract

Cognitive and motor deficits have been proposed as markers of abnormal neurodevelopment in schizophrenia and have been associated with genetic liability. In a multicenter study involving 106 subjects, 56 with deficit schizophrenia and 50 with nondeficit schizophrenia, we tested the hypothesis that the catechol-O-methyltransferase (COMT) Val(158) Met polymorphism is associated with cognitive and motor deficits either in schizophrenia as a whole or in its deficit subtype. The COMT Val(158)Met polymorphism shared 6.6% of the executive/attention dysfunction variance in patients with schizophrenia and 15.6% of the motor impairment variance in patients with deficit schizophrenia. These results support the hypothesis that the COMT Val(158) Met polymorphism influences executive functions in schizophrenia and the neuromotor performance in the deficit subtype only
Catechol-O-methyltransferase, Neuromotor impairment, Dopaminergic system
File in questo prodotto:
File Dimensione Formato  
Neuropsychobiology 2005.pdf

Solo gestori archivio

Tipologia: versione editoriale
Dimensione 139.38 kB
Formato Adobe PDF
139.38 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/21761
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 44
  • ???jsp.display-item.citation.isi??? 43
social impact