The aim of the research project was to investigate whether cell susceptibility to prion infection/replication was somehow related to alterations in the intracellular cholesterol homeostasis, and in particular whether unbalanced FC vs. CE pools could be found in prion infected/prion susceptible cells with respect to cell conditions of no infection or genetic resistance.
Studies on the role of cholesterol in the pathogenesis of prion diseases: I. Correlation between cell susceptibility to prion infection/replication and altered cellular cholesterol distribution
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2007-11-27
Abstract
The aim of the research project was to investigate whether cell susceptibility to prion infection/replication was somehow related to alterations in the intracellular cholesterol homeostasis, and in particular whether unbalanced FC vs. CE pools could be found in prion infected/prion susceptible cells with respect to cell conditions of no infection or genetic resistance.
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