Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational use of these substances is on the rise among young and adult people. The present review summarizes recent findings on the peripheral and central toxicity elicited by "old" and "new" synthetic psychoactive substances in humans and experimental animals, focusing on amphetamine derivatives, hallucinogen and dissociative drugs and synthetic cannabinoids.

Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies

Costa, Giulia
Primo
Writing – Review & Editing
;
De Luca, Maria Antonietta
Writing – Review & Editing
;
Piras, Gessica
Writing – Review & Editing
;
Marongiu, Jacopo
Writing – Review & Editing
;
Fattore, Liana
Writing – Review & Editing
;
Simola, Nicola
Ultimo
Writing – Review & Editing
2020-01-01

Abstract

Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational use of these substances is on the rise among young and adult people. The present review summarizes recent findings on the peripheral and central toxicity elicited by "old" and "new" synthetic psychoactive substances in humans and experimental animals, focusing on amphetamine derivatives, hallucinogen and dissociative drugs and synthetic cannabinoids.
2020
MDMA; NPS; cannabinoids; dissociatives; hallucinogens; ketamine; methamphetamine; methoxetamine; neuroinflammation; neurotoxicity
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/280367
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