Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.

Solvent-free, continuous synthesis of hydrazone-based active pharmaceutical ingredients by twin-screw extrusion

Porcheddu A.;Delogu F.
Membro del Collaboration Group
;
Colacino E.
Writing – Review & Editing
2020-01-01

Abstract

Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.
2020
active pharmaceutical ingredients (APIs); green chemistry; hydantoins; hydrazones; mechanochemistry; solven ree; twin-screw extrusion (TSE)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/300727
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