The adenosine A2A receptor antagonist SCH 58261 increases the turning behavior induced by L-dopa in unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats. In this study we have evaluated the effect of a chronic intermittent administration of L-dopa or SCH 58261 plus L-dopa on turning behaviour. Chronic intermittent administration of SCH 58261 plus L-dopa produced a stable turning behavior during the course of the treatment, whereas L-dopa alone produced a progressive increase in turning behavior. Moreover, repeated administration of SCH 58261 failed to produce tolerance to its ability to potentiate L-dopa-induced turning behavior. The results indicate that SCH 58261 is effective after chronic administration and suggest that SCH 58261 plus L-dopa, differently from L-dopa alone, does not produce alterations in motor responses during the course of the treatment.

Interaction between dopamine and adenosine A2A receptors as a basis for the treatment of Parkinson's disease

MORELLI, MICAELA;
2001-01-01

Abstract

The adenosine A2A receptor antagonist SCH 58261 increases the turning behavior induced by L-dopa in unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats. In this study we have evaluated the effect of a chronic intermittent administration of L-dopa or SCH 58261 plus L-dopa on turning behaviour. Chronic intermittent administration of SCH 58261 plus L-dopa produced a stable turning behavior during the course of the treatment, whereas L-dopa alone produced a progressive increase in turning behavior. Moreover, repeated administration of SCH 58261 failed to produce tolerance to its ability to potentiate L-dopa-induced turning behavior. The results indicate that SCH 58261 is effective after chronic administration and suggest that SCH 58261 plus L-dopa, differently from L-dopa alone, does not produce alterations in motor responses during the course of the treatment.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/3108
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