A general strategy for the synthesis of indolyl cyclobutanones via a tandem Bronsted acid catalyzed 2-hydroxycyclobutanone activation-indole nucleophilic addition has been exploited. The procedure leads to a wide range of 2- and 3-functionalized indole derivatives in good to high yields with broad substrate scope.

A Catalytic One-Pot Synthesis of Indolyl Cyclobutanones

Porcu S.
Primo
;
Frongia A.;Secci F.
Ultimo
2021-01-01

Abstract

A general strategy for the synthesis of indolyl cyclobutanones via a tandem Bronsted acid catalyzed 2-hydroxycyclobutanone activation-indole nucleophilic addition has been exploited. The procedure leads to a wide range of 2- and 3-functionalized indole derivatives in good to high yields with broad substrate scope.
2021
Bronsted acids; Catalysis; Cyclobutanones; Indoles; Tandem reactions
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/317829
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