The development of novel methods for the selective functionalization and transformation of cyclobutanes is of great utility and has received significant attention in organic synthesis. Cyclobutanes play a significant role as building units because they can be easily transformed into a variety of interesting compounds by ring-expansion, -contraction and ring-opening reactions. In this account, we summarize our latest results on the use of 2-hydroxycyclobutanones as starting material of new tandem reactions leading to synthetically relevant nitrogen heterocycles.
Synthesis Of Highly Functionalized Nitrogen Heterocycle From 2-Hydroxycyclobutanones And Aromatic Amines
Secci F.;Frongia A.
2020-01-01
Abstract
The development of novel methods for the selective functionalization and transformation of cyclobutanes is of great utility and has received significant attention in organic synthesis. Cyclobutanes play a significant role as building units because they can be easily transformed into a variety of interesting compounds by ring-expansion, -contraction and ring-opening reactions. In this account, we summarize our latest results on the use of 2-hydroxycyclobutanones as starting material of new tandem reactions leading to synthetically relevant nitrogen heterocycles.
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