Relationships between immune and endocrine systems seem to occur in ovarian follicular fluids (FF). Lymphomonocytes have been found in preovulatory follicles and their specific products, cytokines [interleukin-1 (IL1), IL2], were demonstrated to inhibit steroidogenesis. Ovarian steroids, in turn, reduce the cytokine production from immune-competent cells. In the present study we evaluated whether lymphomonocytes are present in FF, and if both their subset distribution and their IL1α and IL2 secretions, after activation with phytohemagglutinin (PHA), are similar to those of peripheral blood. Interferences of IL1α and IL2 production by FF lymphomonocytes caused by isolated granulosa cells were also evaluated. © 1993 Plenum Publishing Corporation.
Evidence that granulosa cells inhibit interleukin-1α and interleukin-2 production from follicular lymphomonocytes
Maccio Antonio;Mantovani G.;
1993-01-01
Abstract
Relationships between immune and endocrine systems seem to occur in ovarian follicular fluids (FF). Lymphomonocytes have been found in preovulatory follicles and their specific products, cytokines [interleukin-1 (IL1), IL2], were demonstrated to inhibit steroidogenesis. Ovarian steroids, in turn, reduce the cytokine production from immune-competent cells. In the present study we evaluated whether lymphomonocytes are present in FF, and if both their subset distribution and their IL1α and IL2 secretions, after activation with phytohemagglutinin (PHA), are similar to those of peripheral blood. Interferences of IL1α and IL2 production by FF lymphomonocytes caused by isolated granulosa cells were also evaluated. © 1993 Plenum Publishing Corporation.
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