The occurrence of neuropsychiatric manifestations in systemic lupus erythematosus (NPSLE) represents a diagnostic and therapeutic challenge for patients and clinicians. In this article we briefly discuss new perspectives on the pathogenesis, diagnosis, attribution and outcome of NPSLE. We speculated on the possible role of a rigorous preventive strategy, which takes into account the existence of associated risk factors that are yet to be fully defined, in the management of NPSLE. Finally, we highlight the management options and focus on the established and newly available treatment protocols for the more challenging, in terms of frequency or severity, clinical features of NPSLE.
Managing CNS Involvement in Systemic Lupus Erythematosus
PIGA, MATTEO;MATHIEU, ALESSANDRO
2011-01-01
Abstract
The occurrence of neuropsychiatric manifestations in systemic lupus erythematosus (NPSLE) represents a diagnostic and therapeutic challenge for patients and clinicians. In this article we briefly discuss new perspectives on the pathogenesis, diagnosis, attribution and outcome of NPSLE. We speculated on the possible role of a rigorous preventive strategy, which takes into account the existence of associated risk factors that are yet to be fully defined, in the management of NPSLE. Finally, we highlight the management options and focus on the established and newly available treatment protocols for the more challenging, in terms of frequency or severity, clinical features of NPSLE.
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