Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer type, lacking effective therapies and associated with a dismal prognosis. Palbociclib is a selective CDK4/6 inhibitor, which has been shown to suppress cell proliferation in many experimental cancer models. Recently, we demonstrated that pan-mTOR inhibitors, such as MLN0128, effectively induce apoptosis, although have limited efficacy in restraining proliferation of ICC cells. Here, we tested the hypothesis that palbociclib, due to its antproliferative properties in many cancer types, might synergize with MLN0128 to impair ICC growth.

Combined CDK4/6 and pan-mTOR inhibition is synergistic against intrahepatic cholangiocarcinoma

Serra M.;
2019

Abstract

Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer type, lacking effective therapies and associated with a dismal prognosis. Palbociclib is a selective CDK4/6 inhibitor, which has been shown to suppress cell proliferation in many experimental cancer models. Recently, we demonstrated that pan-mTOR inhibitors, such as MLN0128, effectively induce apoptosis, although have limited efficacy in restraining proliferation of ICC cells. Here, we tested the hypothesis that palbociclib, due to its antproliferative properties in many cancer types, might synergize with MLN0128 to impair ICC growth.
Animals
Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Benzoxazoles
Cell Line, Tumor
Cell Proliferation
Cholangiocarcinoma
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase 6
Heterografts
Humans
Mice
Phosphorylation
Piperazines
Protein Kinase Inhibitors
Pyridines
Pyrimidines
TOR Serine-Threonine Kinases
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11584/341634
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