The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin, and N-propionylsaccharin. This protocol furnishes a valuable solvent-free alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.

N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

Basoccu, Francesco;Fattuoni, Claudia
;
Porcheddu, Andrea
2022-01-01

Abstract

The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin, and N-propionylsaccharin. This protocol furnishes a valuable solvent-free alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.
2022
formamides; green chemistry; ball milling; mechanochemistry; saccharin
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/343313
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