Schizophrenia spectrum disorders are among the most debilitating mental disorders and has complex pathophysiological underpinnings. There is growing evidence that brain-derived neurotrophic factor (BDNF) can play a role in its pathogenesis. The present study investigated the longitudinal variation of serum BDNF levels in a 24-month observational prospective cohort study of Sardinian psychotic patients and its relationship with psychopathological and cognitive changes. Furthermore, we examined whether genetic variation within the BDNF gene could moderate these relationships.

Exploring the association between brain-derived neurotrophic factor levels and longitudinal psychopathological and cognitive changes in Sardinian psychotic patients

Isayeva, Ulkar
Writing – Original Draft Preparation
;
Manchia, Mirko
Writing – Original Draft Preparation
;
Collu, Roberto;Deriu, Luca;Caboni, Edoardo;Iaselli, Novella;Sundas, Davide;Tusconi, Massimo;Pinna, Federica;Paribello, Pasquale;Scherma, Maria;Pisanu, Claudia;Meloni, Anna;Congiu, Donatella;Squassina, Alessio;Fratta, Walter;Fadda, Paola
Supervision
;
Carpiniello, Bernardo
Ultimo
Supervision
2022-01-01

Abstract

Schizophrenia spectrum disorders are among the most debilitating mental disorders and has complex pathophysiological underpinnings. There is growing evidence that brain-derived neurotrophic factor (BDNF) can play a role in its pathogenesis. The present study investigated the longitudinal variation of serum BDNF levels in a 24-month observational prospective cohort study of Sardinian psychotic patients and its relationship with psychopathological and cognitive changes. Furthermore, we examined whether genetic variation within the BDNF gene could moderate these relationships.
BDNF; biomarkers; complex disorders; longitudinal trajectories; schizophrenia; Humans; Prospective Studies; Cognition; Polymorphism, Single Nucleotide
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/348235
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