disease represents a model of immune disturbance frequently associated with endocrine impairment. The present study evaluated the effect of the acute administration of \g=b\-interferonor thymopentin on plasma growth hormone, prolactin and cortisol levels in children with Hodgkin's disease (N = 8) and age- and sex-matched healthy controls (N= 8). \g=b\-interferon(1 000 000 IU), thymopentin (50 mg) or placebo (saline) were injected after two basal blood samples (\m=-\15 and 0) and further samples were drawn at 15, 30, 45, 60, 90 and 120 min. Plasma growth hormone, prolactin and cortisol levels were measured by specific RIAs. Plasma prolactin levels did not show significant change following \g=b\x=req-\ interferon or thymopentin injection in either the controls or the patients. In the patients with Hodgkin's disease, \g=b\-interferoninjection induced a significant increase in both plasma growth hormone and cortisol levels, while thymopentin was not effective. In controls both thymopentin and \g=b\-interferon administration increased plasma growth hormone and cortisol levels. These results indicate that \g=b\x=req-\ interferon and thymopentin are immune substances active on the release of growth hormone and cortisol in healthy children. The lack of effect of thymopentin in children with Hodgkin's disease suggests an impairment of the immune-endocrine interaction in these patients.
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|Titolo:||Acute beta-interferon or thymopentin administration increases plasma growth hormone and cortisol levels in children|
|Data di pubblicazione:||1992|
|Tipologia:||1.1 Articolo in rivista|