THE early clinical symptoms of Parkinson's disease (PD) may-he difficult to perceive and are frequently overlooked. Thus, interest has focused on the identification of biological or instrumental markers that may contribute to the early diagnosis of PD, with the aim of introducing neuroprotective therapies at the very start of:illness. Impairment of nigrostriatal dopamine transmission can he visualized in vivo by functional imaging techniques,:but these are rather complex and expensive examinations, available only in selected institutions. Here we show that dopamine content and tyrosine hydroxylase immunoreactivity are reduced in peripheral blood lymphocytes (PBL) in the early stages of PD. These data suggest that PBL may represent a simple and:useful tool with which to identify precociously dopamine impairment in PD

Reduced dopamine in peripheral blood lymphocytes in Parkinson's disease.

DI CHIARA, GAETANO
1999-01-01

Abstract

THE early clinical symptoms of Parkinson's disease (PD) may-he difficult to perceive and are frequently overlooked. Thus, interest has focused on the identification of biological or instrumental markers that may contribute to the early diagnosis of PD, with the aim of introducing neuroprotective therapies at the very start of:illness. Impairment of nigrostriatal dopamine transmission can he visualized in vivo by functional imaging techniques,:but these are rather complex and expensive examinations, available only in selected institutions. Here we show that dopamine content and tyrosine hydroxylase immunoreactivity are reduced in peripheral blood lymphocytes (PBL) in the early stages of PD. These data suggest that PBL may represent a simple and:useful tool with which to identify precociously dopamine impairment in PD
1999
dopamine, Parkinson's disease, peripheral blood lymphocytes, tyrosine hydroxylase ; KeyWords Plus: CHAIN ENZYME-ACTIVITIES, LOCUS-COERULEUS, RECEPTOR GENE, NEUROPATHOLOGY, TRANSPORTERS, EXPRESSION, DIAGNOSIS, SPECT
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/36498
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