In unilaterally 6-hydroxydopamine lesioned rats the ability of two non-peptide delta-opioid agonists, BW 373U86 and SNC 80, to induce motor asymmetries, alone or in combination with low doses of specific D-1 or D-2 agonists, was investigated. BW 373U86 and SNC 80 failed to induce motor asymmetries by themselves, but elicited contralateral turning after pretreatment with a dose of SKF 38393, a D-1 agonist, or quinpirole, a D-2 agonist, which per se did not induce contralateral turning. BW 373U86 also potentiated contralateral turning induced by threshold doses of quinpirole. Facilitation of D-1-dependent contralateral turning was associated with a potentiation of c-fos expression, as estimated by Fos-like immunoreactivity, in the dorsal caudate-putamen, particularly in its lateral aspect. Potentiation of D-2-dependent contralateral turning was associated with a reduction of c-fos expression in the medial caudate-putamen. It is concluded that stimulation of delta-opioid receptors facilitates the expression of D-1 and D-2 responses arising from the denervated striatum.

Dopamine-dependent behavioural stimulation by non-peptide delta opioids BW 373U86 and SNC 80: 3. Facilitation of D1 and D2 responses in unilaterally 6-hydroxydopamine-lesioned rats.

DI CHIARA, GAETANO
1998-01-01

Abstract

In unilaterally 6-hydroxydopamine lesioned rats the ability of two non-peptide delta-opioid agonists, BW 373U86 and SNC 80, to induce motor asymmetries, alone or in combination with low doses of specific D-1 or D-2 agonists, was investigated. BW 373U86 and SNC 80 failed to induce motor asymmetries by themselves, but elicited contralateral turning after pretreatment with a dose of SKF 38393, a D-1 agonist, or quinpirole, a D-2 agonist, which per se did not induce contralateral turning. BW 373U86 also potentiated contralateral turning induced by threshold doses of quinpirole. Facilitation of D-1-dependent contralateral turning was associated with a potentiation of c-fos expression, as estimated by Fos-like immunoreactivity, in the dorsal caudate-putamen, particularly in its lateral aspect. Potentiation of D-2-dependent contralateral turning was associated with a reduction of c-fos expression in the medial caudate-putamen. It is concluded that stimulation of delta-opioid receptors facilitates the expression of D-1 and D-2 responses arising from the denervated striatum.
1998
BW 373U86, caudate-putamen, delta opioid receptors, dopamine, rat, SNC 80, turning behaviour ; KeyWords Plus: C-FOS EXPRESSION, STRIATOPALLIDAL NEURONS, TURNING BEHAVIOR, RECEPTORS, BLOCKADE, D1, AGONISTS, POTENT, MODEL, GENE
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/36584
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