Imidazenil, a new partial benzodiazepine receptor agonist, failed to change GABAA receptor function in the brain of untreated mice. On the contrary, this drug reduced both the increase of [35S]TBPS binding and the convulsions elicited by isoniazid. The results suggest that imidazenil has a greater pharmacological efficacy when the GABAergic transmission is reduced
Isoniazid-induced inhibition of GABAergic transmission enhances the efficacy of imidazenil, a new partial agonist of benzodiazepine receptors
SERRA, MARIANGELA;
1993-01-01
Abstract
Imidazenil, a new partial benzodiazepine receptor agonist, failed to change GABAA receptor function in the brain of untreated mice. On the contrary, this drug reduced both the increase of [35S]TBPS binding and the convulsions elicited by isoniazid. The results suggest that imidazenil has a greater pharmacological efficacy when the GABAergic transmission is reduced
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