Imidazenil, a new partial benzodiazepine receptor agonist, failed to change GABAA receptor function in the brain of untreated mice. On the contrary, this drug reduced both the increase of [35S]TBPS binding and the convulsions elicited by isoniazid. The results suggest that imidazenil has a greater pharmacological efficacy when the GABAergic transmission is reduced
Isoniazid-induced inhibition of GABAergic transmission enhances the efficacy of imidazenil, a new partial agonist of benzodiazepine receptors
SERRA, MARIANGELA;
1993-01-01
Abstract
Imidazenil, a new partial benzodiazepine receptor agonist, failed to change GABAA receptor function in the brain of untreated mice. On the contrary, this drug reduced both the increase of [35S]TBPS binding and the convulsions elicited by isoniazid. The results suggest that imidazenil has a greater pharmacological efficacy when the GABAergic transmission is reduced
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I metadati presenti in IRIS UNICA sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono protetti da diritto d'autore, salvo diversa indicazione.
