In the present study serum lipoproteins were investigated during cell proliferation induced by a potent mitogen, lead nitrate. A strong decrease in HDL 2 and a concomitant increase in HDL 3 were observed in lead-treated rats. The recovery of normal lipoprotein pattern took place together with the regression of hyperplastic process. Since a decrease in HDL also occurs under other conditions of cell growth, we hypothesize that a decrease in HDL, mainly in HDL 2 subfraction, may represent a generalized phenomenon related to massive cell proliferation.
VARIATIONS OF SERUM LIPOPROTEINS DURING CELL PROLIFERATION INDUCED BY LEAD NITRATE
FADDA, ANNA MARIA;
1989-01-01
Abstract
In the present study serum lipoproteins were investigated during cell proliferation induced by a potent mitogen, lead nitrate. A strong decrease in HDL 2 and a concomitant increase in HDL 3 were observed in lead-treated rats. The recovery of normal lipoprotein pattern took place together with the regression of hyperplastic process. Since a decrease in HDL also occurs under other conditions of cell growth, we hypothesize that a decrease in HDL, mainly in HDL 2 subfraction, may represent a generalized phenomenon related to massive cell proliferation.
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