Pedigrees of manic-depressive patients in treatment of the Lithium Clinic of the Institute of Clinical Pharmacology, University of Cagliari, were evaluated for linkage between major affective illness and the protan-deutan-glucose-6-phosphate-dehydrogenase region of the X-chromosome. Two informative pedigrees were found, investigated and analyzed for linkage using a multigenerational model and considering age-dependent penetrance. The results are consistent with the hypothesis of X-linkage in major affective illness.

Linkage between X-chromosome markers and mainc-depressive illness

DEL ZOMPO, MARIA;BOCCHETTA, ALBERTO;
1984-01-01

Abstract

Pedigrees of manic-depressive patients in treatment of the Lithium Clinic of the Institute of Clinical Pharmacology, University of Cagliari, were evaluated for linkage between major affective illness and the protan-deutan-glucose-6-phosphate-dehydrogenase region of the X-chromosome. Two informative pedigrees were found, investigated and analyzed for linkage using a multigenerational model and considering age-dependent penetrance. The results are consistent with the hypothesis of X-linkage in major affective illness.
1984
Bipolar manic depressive illness; X-linkage; Genetics
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/393
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