The synthesis of the [H-3] labelled peripheral benzodiazepine receptor (PBR) ligand CB 34, useful for binding assay, tissue distribution studies, and elucidation of the physiological role of PER, is described. Catalytic reduction with H-3(2) gas and 10% Pd/C catalyst of the key intermediate 2 afforded the product at a specific activity of 111 Ci/mmol. Copyright (C) 2001 John Wiley & Sons, Ltd.
Synthesis of the [H-3] labelled potent and selective peripheral benzodiazepine receptor ligand CB 34
SERRA, MARIANGELA;
2001-01-01
Abstract
The synthesis of the [H-3] labelled peripheral benzodiazepine receptor (PBR) ligand CB 34, useful for binding assay, tissue distribution studies, and elucidation of the physiological role of PER, is described. Catalytic reduction with H-3(2) gas and 10% Pd/C catalyst of the key intermediate 2 afforded the product at a specific activity of 111 Ci/mmol. Copyright (C) 2001 John Wiley & Sons, Ltd.
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