Diastereomeric forms of 1-(pyrrolidin-1-ylmethyl)-2-(N-methyl)-4-[(3,4-dichloro)phenyl]-1,2,3,4- tetrahydroisoquinoline-3(2h)-ones 3a and its chloro analog 3c were synthesized. Compounds 3a,c are related to the kappa-selective opiate ICI 199441 1 by linking the benzylic CH2 to the ortho position of the phenyl in 1. Compared with morphine, these compounds had lost in kappa and mu affinities; only cis-3a showed a modest kappa affinity. 1-Pyrrolidin-1-ylmethyl-N-[2-(3,4-dichlorphenyl)acetyl]-1,2,3,4-tetrahyd roisoquinoline 2, which is also a cyclic congener of 1, was reported to display high kappa and mu affinity, and so a conformational study was undertaken on 1, 2 and 3a. This showed that, while active 2 extensively superposed on 1, 3a assumes another geometry which does not allow a fit with the pharmacophoric moieties of 1 and 2.
SYNTHESIS AND KAPPA-BINDING-AFFINITY OF 1-(PYRROLIDIN-1-YLMETHYL)-2-(N-METHYL)-4-[(3,4-DICHLORO)PHENYL]-1,2,3,4- TETRAHYDROISOQUINOLIN-3(2H)-ONES
FADDA, PAOLA
1995-01-01
Abstract
Diastereomeric forms of 1-(pyrrolidin-1-ylmethyl)-2-(N-methyl)-4-[(3,4-dichloro)phenyl]-1,2,3,4- tetrahydroisoquinoline-3(2h)-ones 3a and its chloro analog 3c were synthesized. Compounds 3a,c are related to the kappa-selective opiate ICI 199441 1 by linking the benzylic CH2 to the ortho position of the phenyl in 1. Compared with morphine, these compounds had lost in kappa and mu affinities; only cis-3a showed a modest kappa affinity. 1-Pyrrolidin-1-ylmethyl-N-[2-(3,4-dichlorphenyl)acetyl]-1,2,3,4-tetrahyd roisoquinoline 2, which is also a cyclic congener of 1, was reported to display high kappa and mu affinity, and so a conformational study was undertaken on 1, 2 and 3a. This showed that, while active 2 extensively superposed on 1, 3a assumes another geometry which does not allow a fit with the pharmacophoric moieties of 1 and 2.
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