Interaction of methimazole (MMI, 1-methyl-imidazole-2-thione) with I2 in solvents having different polarity gives two new stable compounds containing a dication disulfide and a monocation disulfide arranged in dimers, respectively. These two species could represent effective intermediates in the reaction of MMI with an active iodine species in the thyroid gland and therefore shed more light on the mechanism of action of MMI as an antithyroid drug.
Anti-thyroid drug methimazole: X-ray characterisation of two novel ionic disulfides obtained from its chemical oxidation by I2
ARAGONI, MARIA CARLA;ARCA, MASSIMILIANO;ISAIA, FRANCESCO;LIPPOLIS, VITO;
2002-01-01
Abstract
Interaction of methimazole (MMI, 1-methyl-imidazole-2-thione) with I2 in solvents having different polarity gives two new stable compounds containing a dication disulfide and a monocation disulfide arranged in dimers, respectively. These two species could represent effective intermediates in the reaction of MMI with an active iodine species in the thyroid gland and therefore shed more light on the mechanism of action of MMI as an antithyroid drug.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
jacs02.pdf
Solo gestori archivio
Tipologia:
versione editoriale (VoR)
Dimensione
49.06 kB
Formato
Adobe PDF
|
49.06 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I metadati presenti in IRIS UNICA sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono protetti da diritto d'autore, salvo diversa indicazione.
