The antimalarial drug quinacrine has been used experimentally as an inhibitor of phospholipase A(2) and as a cell membrane stabilizer. Recent studies have shown that it may interact with the acetylcholine receptor antagonist effect. The cholinergic response is an important factor in the control of the bronchial tone. We have now examined the effect of quinacrine on acetylcholine-induced broncoconstriction in isolated, pet-fused and ventilated rat lung. Quinacrine pretreatment significantly inhibited the decrease in lung compliance and conductance induced by acetylcholine alone. This suggests that the drug may act as an acetylcholine inhibitor, so affecting the bronchial tone of the lung. Med Sci Res 27:811-812 (C) 1999 Lippincott Williams & Wilkins.
Inhibition by quinacrine of acetylcholine-induced broncoconstriction in isolated and perfused rat lung
ATZORI, LUIGI
1999-01-01
Abstract
The antimalarial drug quinacrine has been used experimentally as an inhibitor of phospholipase A(2) and as a cell membrane stabilizer. Recent studies have shown that it may interact with the acetylcholine receptor antagonist effect. The cholinergic response is an important factor in the control of the bronchial tone. We have now examined the effect of quinacrine on acetylcholine-induced broncoconstriction in isolated, pet-fused and ventilated rat lung. Quinacrine pretreatment significantly inhibited the decrease in lung compliance and conductance induced by acetylcholine alone. This suggests that the drug may act as an acetylcholine inhibitor, so affecting the bronchial tone of the lung. Med Sci Res 27:811-812 (C) 1999 Lippincott Williams & Wilkins.
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