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EnglishNeuroinflammation is a major pathological component of Parkinson’s disease. Chronic microglial response dominates the histopathology of parkinsonian substantia nigra. In addition infiltrated T lymphocytes in the brain parenchyma and abnormally activated T lymphocytes in the blood of patients with Parkinson’s disease have been described. In less than a decade the concept of Parkinson’s disease neuropathology has been profoundly revised. It is now evident that neurotoxic microgliosis is only part of a more complex dysregulation of the immune response, that involves both the central and peripheral immune systems.
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| Titolo: | The role of microglia–lymphocyte interaction in PD neuropathology |
| Autori: | |
| Data di pubblicazione: | 2012 |
| Rivista: | |
| Abstract: | Neuroinflammation is a major pathological component of Parkinson’s disease. Chronic microglial response dominates the histopathology of parkinsonian substantia nigra. In addition infiltrated T lymphocytes in the brain parenchyma and abnormally activated T lymphocytes in the blood of patients with Parkinson’s disease have been described. In less than a decade the concept of Parkinson’s disease neuropathology has been profoundly revised. It is now evident that neurotoxic microgliosis is only part of a more complex dysregulation of the immune response, that involves both the central and peripheral immune systems. |
| Handle: | http://hdl.handle.net/11584/44203 |
| Tipologia: | 1.1 Articolo in rivista |
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