An Efficient Strategy for Quinazolinone and Benzimidazole Synthesis Using Microwave-Assisted Copper-Catalyzed Aerobic Oxidation of Amines

Microwave-assisted organic synthesis (MAOS) has emerged as an effective technique for accelerating chemical reactions while enhancing efficiency and selectivity. In this study, we developed a copper-catalyzed method for aerobic oxidative coupling to synthesize quinazolinones and benzimidazoles, using oxone as the oxidant under microwave irradiation. This method successfully couples amines with various partners, including 2-aminobenzamides and o-phenylenediamines. The strategy demonstrates broad substrate compatibility, exhibits good functional group tolerance, and consistently achieves moderate yields, making it a versatile and efficient approach for synthesizing heterocycles.