Pyrazole related nucleosides 5. Synthesis and biological activity of 2'-deoxy-2',3'-dideoxy- and acyclo-analogues of 4-iodo-1b-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR)

Manfredini, S; BARALDI P., G; Bazzanini, R; Durini, E; Vertuani, S; Pani, Alessandra; Marceddu, T; Demontis, F; Vargiu, L; LA COLLA, P.

doi:10.1080/15257770008035019

Continuing our studies on the structure-activity relationships (SAR) of 4-iodo-1-beta-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR), the ribofuranosyl moiety has been substituted with acyclic chains, namely 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]-pyrazole derivatives (4, 5 and 8, 9 respectively), with the 2'-deoxy-beta-D-ribofuranosyl group (12 and 13) and finally with the 2',3'-dideoxy-D-glycero-pentofuranosyl-moiety (16 and 17). None of the new compounds display any interesting biological activity.

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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11584/4460

Titolo:	Pyrazole related nucleosides 5. Synthesis and biological activity of 2'-deoxy-2',3'-dideoxy- and acyclo-analogues of 4-iodo-1b-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR)
Autori:	MANFREDINI S BARALDI P. G BAZZANINI R DURINI E VERTUANI S PANI, ALESSANDRA MARCEDDU T DEMONTIS F VARGIU L LA COLLA P. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2000
Rivista:	NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS
Abstract:	Continuing our studies on the structure-activity relationships (SAR) of 4-iodo-1-beta-D-ribofuranosyl-3-carboxymethyl pyrazole (IPCAR), the ribofuranosyl moiety has been substituted with acyclic chains, namely 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]-pyrazole derivatives (4, 5 and 8, 9 respectively), with the 2'-deoxy-beta-D-ribofuranosyl group (12 and 13) and finally with the 2',3'-dideoxy-D-glycero-pentofuranosyl-moiety (16 and 17). None of the new compounds display any interesting biological activity.
Handle:	http://hdl.handle.net/11584/4460
Tipologia:	1.1 Articolo in rivista

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