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EnglishAbstract Thirty-six patients with Raynaud's disease (RD) were treated with a low dosage of β-blockers, atenolol (50 mg/day) or propranolol (20 mg/day). Previous data have suggested that the pathophysiology of RD may be mediated by presynaptic β-adrenoceptors. In this research we report that chronic β-blocker treatment, at low dosage, can prevent the cold-induced vasospasm. The majority of patients (28) responded to atenolol, and 8 patients refractory to atenolol responded to propranolol.
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| Titolo: | β-Blockers: A new therapeutic approach to Raynaud's disease |
| Autori: | |
| Data di pubblicazione: | 1987 |
| Rivista: | |
| Abstract: | Abstract Thirty-six patients with Raynaud's disease (RD) were treated with a low dosage of β-blockers, atenolol (50 mg/day) or propranolol (20 mg/day). Previous data have suggested that the pathophysiology of RD may be mediated by presynaptic β-adrenoceptors. In this research we report that chronic β-blocker treatment, at low dosage, can prevent the cold-induced vasospasm. The majority of patients (28) responded to atenolol, and 8 patients refractory to atenolol responded to propranolol. |
| Handle: | http://hdl.handle.net/11584/45532 |
| Tipologia: | 1.1 Articolo in rivista |
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