Xanthine Oxidase is overexpressed in inflamed mucosa of IBD patients, promoting NLRP3 inflammasome activation and proinflammatory cytokine release. Ex vivo inhibition of Xanthine Oxidase by febuxostat or allopurinol suppressed inflammation representing a potential therapeutic approach for inflammatory bowel disease.
Xanthine Oxidase-Dependent Activation of NLPR3 Inflammasome in Epithelial Cells Sustains Inflammation in Inflammatory Bowel Disease
Di Petrillo, AmaliaPrimo
Conceptualization
;Fais, Antonella;Raho, Nicola;Era, Benedetta;Cannea, Faustina Barbara;Padiglia, Alessandra;Grecu, Eleonora;Murtas, Daniela;Maxia, Cristina;Sogos, Valeria;Porcedda, Clara;Caboni, Pierluigi;Demurtas, Mauro;Favale, AgneseWriting – Review & Editing
;Onali, SaraPenultimo
Writing – Review & Editing
;Fantini, Massimo Claudio
Ultimo
Conceptualization
2025-01-01
Abstract
Xanthine Oxidase is overexpressed in inflamed mucosa of IBD patients, promoting NLRP3 inflammasome activation and proinflammatory cytokine release. Ex vivo inhibition of Xanthine Oxidase by febuxostat or allopurinol suppressed inflammation representing a potential therapeutic approach for inflammatory bowel disease.
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