Morphine (10 and 20 mg/kg, s.c.) does not modify dopamine release in the nucleus accumbens of cannabinoid CB1 knock-out mice under conditions where it dose-dependently stimulates the release of dopamine in the corresponding wild-type mice. These results demonstrate that cannabinoid CB1 receptors, regulate mesolimbic dopaminergic transmission in brain areas known to be involved in the reinforcing effects of morphine. (C) 1999 Elsevier Science B.V. All rights reserved.
Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB1 receptor knock-out mice
FRATTA, WALTER
1999-01-01
Abstract
Morphine (10 and 20 mg/kg, s.c.) does not modify dopamine release in the nucleus accumbens of cannabinoid CB1 knock-out mice under conditions where it dose-dependently stimulates the release of dopamine in the corresponding wild-type mice. These results demonstrate that cannabinoid CB1 receptors, regulate mesolimbic dopaminergic transmission in brain areas known to be involved in the reinforcing effects of morphine. (C) 1999 Elsevier Science B.V. All rights reserved.
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