UNICA IRIS Institutional Research Information System
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Cagliari dal mese di luglio 2015.
EnglishTo study the effect of the sulfate ester moiety on the opioid activity, we prepared two tyrosine sulfate-(Tyr(SO3H)-containing dermorphin and deltorphin peptides. Their activities were determined in binding studies based on displacement of mu- and delta-receptor selective radiolabels from rat brain membranes and in two bioassays, using guinea pig ileum and mouse vas deferens. In comparison to original peptides and morphine, the obtained data indicate that whereas H-Tyr(SO3H)-D-Ala-Phe-Gly-NH2 shows very minimal interaction with opioid receptors, H-Tyr(SO3H)-D-Ala-Phe-Asp-Val-Val-Gly-NH2 retains a significant activity.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | Synthesis and Opioid Activity of tyrosine sulfate containing dermorphin and Deltorphin Peptides | |
| Autori: | ||
| Data di pubblicazione: | 1995 | |
| Rivista: | ||
| Abstract: | To study the effect of the sulfate ester moiety on the opioid activity, we prepared two tyrosine sulfate-(Tyr(SO3H)-containing dermorphin and deltorphin peptides. Their activities were determined in binding studies based on displacement of mu- and delta-receptor selective radiolabels from rat brain membranes and in two bioassays, using guinea pig ileum and mouse vas deferens. In comparison to original peptides and morphine, the obtained data indicate that whereas H-Tyr(SO3H)-D-Ala-Phe-Gly-NH2 shows very minimal interaction with opioid receptors, H-Tyr(SO3H)-D-Ala-Phe-Asp-Val-Val-Gly-NH2 retains a significant activity. | |
| Handle: | http://hdl.handle.net/11584/6712 | |
| Tipologia: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11584/6712
Copyright © 2022