Using the potent cyclic peptide T analog [formula: see text] as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. [formula: see text] showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.

Structure-activity ralationships of cyclic and linear peptide T analogues

BALBONI, GIANFRANCO;
1993-01-01

Abstract

Using the potent cyclic peptide T analog [formula: see text] as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. [formula: see text] showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.
1993
BIODEGRADATION; CHEMOTACTIC ACTIVITY; HOMOSERINE INTO SYNTHETIC PEPTIDES; PEPTIDE-T CYCLIC ANALOGS
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/6715
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