Using the potent cyclic peptide T analog [formula: see text] as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. [formula: see text] showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.

Structure-activity ralationships of cyclic and linear peptide T analogues

BALBONI, GIANFRANCO;
1993

Abstract

Using the potent cyclic peptide T analog [formula: see text] as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. [formula: see text] showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.
BIODEGRADATION; CHEMOTACTIC ACTIVITY; HOMOSERINE INTO SYNTHETIC PEPTIDES; PEPTIDE-T CYCLIC ANALOGS
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11584/6715
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