The pyrrolo[1,2-f ]phenanthridines 8–22 and the corresponding non-rigid analogues 23–41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16–18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.
File in questo prodotto:
Non ci sono file associati a questo prodotto.