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EnglishThe pyrrolo[1,2-f ]phenanthridines 8–22 and the corresponding non-rigid analogues 23–41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16–18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.
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| Titolo: | Pirrolo [1,2-f] phenanthridines and related non-rigid analogues as antiviral agents |
| Autori interni: | LODDO, ROBERTA |
| Data di pubblicazione: | 2002 |
| Rivista: | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY |
| Abstract: | The pyrrolo[1,2-f ]phenanthridines 8–22 and the corresponding non-rigid analogues 23–41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16–18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition. |
| Handle: | http://hdl.handle.net/11584/6946 |
| Tipologia: |
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