Monocarboxylate Transporter 1 (MCT1) mediates the transport of the main fraction of lactate across the sarcolemma. Symptoms and signs of muscle injury on exercise and heat exposure plus subnormal erythrocyte lactate transport have been related with the presence of two mutations in the gene that codifies MCT1. PURPOSE: We investigated the influence of MCT1 A1470T polymorphism (rs1049434) on indirect muscle injuries rates in top-level soccer players. METHODS: A sample of 70 elite male soccer players (age 26.5± 4.5 years; stature 181.9±6.6 cm; weight 77.7±6.4 kg) were analyzed during four seasons (form 2009-2010 till 2012-2013). Injury rates (IR) (injuries per 1000 hours of soccer exposure) during seasons as well as prevalence, severity, and type of injuries were considered. The influence of MCT1 A1470T polymorphism on indirect muscle injuries was examined using the one-way ANOVA. RESULTS: The estimated total incidence was 0.2 indirect muscles injuries per 1000 hours of exposure. The 30 injuries recorded during the four seasons accounted for a loss of 850 days, that is, absence from training in the pre-season and regular competitive season. No significant differences appeared between athletes with different genotypes and injuries rates (p>0.05). However, during the four seasons, we found a trend toward an higher injuries rates in athletes with AA and AT genotypes respect to those with TT genotype (2009-2010 IR; AA=0.16, AT=0.13, TT=0.03; 2010-2011 IR; AA=0.32; AT=0.24; TT=0.02; 2011-2012 IR; AA=0.25; AT=0.06; 2012-2013 IR; AA=2.25; AT=0.69; TT=0.63). CONCLUSIONS: In our limited sample, the MCT1 A1470T polymorphism did not seem to make a significant contribution to the pathogenesis of indirect muscle injuries in top-level soccer players. However, the trend toward an high injuries rates in athletes with AA and AT genotypes suggests that further future analysis are require to better clarify the possible influence of MCT1 polymorphism on muscle injuries in soccer.
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|Titolo:||Influence of MCT1 A1470T Polymorphism on Muscle Injuries Among Elite Italian Soccer Players|
MASSIDDA, MYOSOTIS (Primo)
|Data di pubblicazione:||2013|
|Tipologia:||1.5 Abstract in rivista|