The core structure of cis-3,5-diaminopiperidine was N-alkylated with excess t-butylbromoacetate in order to exploit the successive N-quaternarization and Stevens rearrangement to access the pentaalkylated product and the bifunctional chelating agent containing a N-butanedioic acid pendant arm at the same time. The relaxometric properties of the Gd III complexes with these ligands were studied also in terms of pH and serum stabilities.
One-pot synthesis of a piperidine-based rigidified DTPA analogue and its bifunctional chelating agent
TEI, LORENZO;
2012-01-01
Abstract
The core structure of cis-3,5-diaminopiperidine was N-alkylated with excess t-butylbromoacetate in order to exploit the successive N-quaternarization and Stevens rearrangement to access the pentaalkylated product and the bifunctional chelating agent containing a N-butanedioic acid pendant arm at the same time. The relaxometric properties of the Gd III complexes with these ligands were studied also in terms of pH and serum stabilities.File in questo prodotto:
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