The clinical problems connected to iron overload in P-thalassemia are briefly summarized and the need for finding proper iron chelators is presented. The biological, pharmacological and clinical requirements for an ideal iron chelator are discussed. Some chemical considerations on iron chelators as well as a survey on chemical compounds tested up to now are presented.
Oral iron chelators for clinical use
CRISPONI, GUIDO;NURCHI, VALERIA MARINA;FAA G.
1999-01-01
Abstract
The clinical problems connected to iron overload in P-thalassemia are briefly summarized and the need for finding proper iron chelators is presented. The biological, pharmacological and clinical requirements for an ideal iron chelator are discussed. Some chemical considerations on iron chelators as well as a survey on chemical compounds tested up to now are presented.
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