The COCs evolution has been obtained with new and differents progestinic compounds associated with lower doses of EE (ethinylestradiol). The revo- lution in the COCs field is the introduction of estra- diol valerate (E2V), ester of the natural estrogen, estradiol (E2) instead of EE. Dienogest (DNG) is the progestinic compound of the COC Klaira associated with E2V in a multiphase formulation. DNG has a strong antiandrogenetic action without the mineral- corticoid and glucocorticoid action and E2V acts in this association improving the subjective sleep quality, somatic complaints, anxiety, vigilance, cog- nition and numerical memory. The EE/DRSP(drospirenone) association (Yaz®) has a progestinic compound characterized by antimineralcorticoid and antiandrogenic properties with a positive effect on psychological symptoms. In this prospective study we evaluated if E2V is able to exert the same psychological symptoms as EE/DRSP formulation. Psychological changes were evaluated with SCL90 for 5 cycles. In comparison with the basal value the score was significantly reduced (p<0,001) during both treatments. This effects observed confirm that DNG and DRSP act with beneficial effects on CNS.
The 12-month treatment with the oral contraceptive formulation containing dienogest (DNG) and estradiol valerate (E2V) shows beneficial effects on psychological symptoms: results from a prospective comparative study with a formulation containing ethinyl estradiol (EE) and drospirenone (DRSP)
MELIS, GIAN BENEDETTO;PAOLETTI, ANNA MARIA
2013-01-01
Abstract
The COCs evolution has been obtained with new and differents progestinic compounds associated with lower doses of EE (ethinylestradiol). The revo- lution in the COCs field is the introduction of estra- diol valerate (E2V), ester of the natural estrogen, estradiol (E2) instead of EE. Dienogest (DNG) is the progestinic compound of the COC Klaira associated with E2V in a multiphase formulation. DNG has a strong antiandrogenetic action without the mineral- corticoid and glucocorticoid action and E2V acts in this association improving the subjective sleep quality, somatic complaints, anxiety, vigilance, cog- nition and numerical memory. The EE/DRSP(drospirenone) association (Yaz®) has a progestinic compound characterized by antimineralcorticoid and antiandrogenic properties with a positive effect on psychological symptoms. In this prospective study we evaluated if E2V is able to exert the same psychological symptoms as EE/DRSP formulation. Psychological changes were evaluated with SCL90 for 5 cycles. In comparison with the basal value the score was significantly reduced (p<0,001) during both treatments. This effects observed confirm that DNG and DRSP act with beneficial effects on CNS.
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