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EnglishLipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner. Dietary conjugated linoleic acid (CLA) is a fatty acid with a conjugated diene structure that is found in low concentrations in ruminant products and available as a nutritional supplement. CLA has been shown to increase tissue levels of retinol (vitamin A alcohol) and its sole specific circulating carrier protein retinol-binding protein (RBP or RBP4). However, the precise mechanism of this action has not been elucidated yet. Here, we provide a summary of the current knowledge in this specific area of research and speculate that retinol and CLA may compete for catabolic pathways modulated by the activity of PPAR- and RXR heterodimer. We also present preliminary data that may position PPAR- at the crossroads between the metabolism of lipids and vitamin A
| Titolo: | Metabolic interactions between vitamin A and conjugated linoleic acid |
| Autori: | CARTA, GIANFRANCA (Primo) BANNI, SEBASTIANO (Corresponding) |
| Data di pubblicazione: | 2014 |
| Rivista: | |
| Handle: | http://hdl.handle.net/11584/99337 |
| Tipologia: | 1.1 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| nutrients vit A and CLA review.pdf | versione editoriale | Open Access Visualizza/Apri |
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