The reinforcing effects of gamma-hydroxybutyric acid (GHB) were studied by means of intravenous self-administration in drug-naive mice. GHB self-administration was concentration-dependent (0.01-0.5 mg/kg/inj) according to a bell-shaped curve. Pretreatment with the specific GHB receptor antagonist NCS-382 at a dose of 12.5 mg/kg i.p. completely antagonized the reinforcing effects of GHB. These data suggest that GHB is able to induce reinforcing effects in mice and support the hypothesis of an abuse liability of this drug. (C) 1998 Elsevier Science B.V./ECNP. All rights reserved.
Intravenous self-administration of gamma-hydroxybutyric acid in drug-naive mice
COSSU, GREGORIO;FRATTA, WALTER
1998-01-01
Abstract
The reinforcing effects of gamma-hydroxybutyric acid (GHB) were studied by means of intravenous self-administration in drug-naive mice. GHB self-administration was concentration-dependent (0.01-0.5 mg/kg/inj) according to a bell-shaped curve. Pretreatment with the specific GHB receptor antagonist NCS-382 at a dose of 12.5 mg/kg i.p. completely antagonized the reinforcing effects of GHB. These data suggest that GHB is able to induce reinforcing effects in mice and support the hypothesis of an abuse liability of this drug. (C) 1998 Elsevier Science B.V./ECNP. All rights reserved.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Martellotta et al EurNeuroPsycho_1998.pdf
Solo gestori archivio
Tipologia:
versione editoriale (VoR)
Dimensione
70.17 kB
Formato
Adobe PDF
|
70.17 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I metadati presenti in IRIS UNICA sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono protetti da diritto d'autore, salvo diversa indicazione.
