A novel mathematical model to simulate the growth of engineered cartilage on polymeric scaffolds performed in rotating bioreactors is proposed. The dynamic-spatial behavior ofthe nutrient species (oxygen) and the primary extra-cellular matrix product (GAG) are quantitatively described through the proposed model where the simulation ofcell proliferation and its distribution within the polymeric scaffold is improved with respect to the existing literature by properly taking into account suitable population balances. Model results and literature experimental data in terms ofGA G contents and its distribution within the tissue construct have been successfully compared, thus demonstrating the validity ofthe proposed model as well as its predictive capability.
Modeling of engineered cartilage growth in rotating bioreactors
LAI N;CINCOTTI, ALBERTO;CONCAS A;CAO, GIACOMO
2004-01-01
Abstract
A novel mathematical model to simulate the growth of engineered cartilage on polymeric scaffolds performed in rotating bioreactors is proposed. The dynamic-spatial behavior ofthe nutrient species (oxygen) and the primary extra-cellular matrix product (GAG) are quantitatively described through the proposed model where the simulation ofcell proliferation and its distribution within the polymeric scaffold is improved with respect to the existing literature by properly taking into account suitable population balances. Model results and literature experimental data in terms ofGA G contents and its distribution within the tissue construct have been successfully compared, thus demonstrating the validity ofthe proposed model as well as its predictive capability.
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