Bipolar disorder (BD) is a highly heterogeneous and heritable psychiatric illness. Age at onset has been shown to be a powerful tool for dissecting both the phenotypic and genetic complexity of BD. In this article, we present findings from an association study between the DRD2 TaqIA polymorphism and age at onset, showing that both alleles and genotypes at this locus associate with early onset BD.
Age at onset in bipolar disorder: investigation of the role of TaqIA polymorphism of DRD2 gene in a Sardinian sample
SQUASSINA, ALESSIO;MANCHIA, MIRKO;COSTA, MARTA;DEL ZOMPO, MARIA;SEVERINO, GIOVANNI
2011-01-01
Abstract
Bipolar disorder (BD) is a highly heterogeneous and heritable psychiatric illness. Age at onset has been shown to be a powerful tool for dissecting both the phenotypic and genetic complexity of BD. In this article, we present findings from an association study between the DRD2 TaqIA polymorphism and age at onset, showing that both alleles and genotypes at this locus associate with early onset BD.
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