A series of amides of ibuprofen with heteroaromatic amines was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to parent ibuprofen some of the new amides exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.
Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties
CONGIU, CENZO;ONNIS, VALENTINA;MORELLI, MICAELA;
2003-01-01
Abstract
A series of amides of ibuprofen with heteroaromatic amines was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to parent ibuprofen some of the new amides exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
2003 Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties.pdf
Solo gestori archivio
Dimensione
218.92 kB
Formato
Adobe PDF
|
218.92 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
