Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones

Onnis, Valentina; Demurtas, Monica; Deplano, Alessandro; Balboni, Gianfranco; Baldisserotto, A; Manfredini, S; Pacifico, S; Liekens, S; Balzarini, J.

doi:10.3390/molecules21050579

The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N1-(4-arylidene)-1H-benzo[d]imidazole-2- carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human pancreas carcinoma cells (Mia Paca-2). A preliminary structure-activity relationship could be defined. Some of the compounds possess encouraging and consistent antiproliferative activity, having IC50 values in the low micromolar range

Trovami (UniCASearch)

Titolo:	Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones
Autori:	ONNIS, VALENTINA DEMURTAS, MONICA DEPLANO, ALESSANDRO BALBONI, GIANFRANCO Baldisserotto, A Manfredini, S Pacifico, S Liekens, S Balzarini, J. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2016
Rivista:	MOLECULES
Handle:	http://hdl.handle.net/11584/145433
Tipologia:	1.1 Articolo in rivista

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Benzoimidazoloidrazoni_molecules_2016.pdf	Articolo principale	versione editoriale		Open Access Visualizza/Apri

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11584/145433

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