The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N1-(4-arylidene)-1H-benzo[d]imidazole-2- carbohydrazides were evaluated for their cytostatic activity toward the murine leukemia (L1210), human T-cell leukemia (CEM), human cervix carcinoma (HeLa) and human pancreas carcinoma cells (Mia Paca-2). A preliminary structure-activity relationship could be defined. Some of the compounds possess encouraging and consistent antiproliferative activity, having IC50 values in the low micromolar range
Titolo: | Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones | |
Autori: | ||
Data di pubblicazione: | 2016 | |
Rivista: | ||
Handle: | http://hdl.handle.net/11584/145433 | |
Tipologia: | 1.1 Articolo in rivista |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
Benzoimidazoloidrazoni_molecules_2016.pdf | Articolo principale | versione editoriale | Open Access Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.