Chemical investigation of the stems of Seseli praecox (Gamisans) Gamisans, an endemic Apiaceae from Sardinia, afforded an isopropenylated chromone (5-hydroxy-6-(2-Z-butenyl-3-hydroxymethyl)-7-methoxy-2-methylchromone), along with four known linear furocoumarins and their natural precursor. For biological characterization the new compound was screened against four cancer cell lines in vitro and showed differential mu M antiproliferative effects between suspension and adherent cells.
A chromone from Seseli praecox (Apiaceae)
LEONTI, MARCO;CASU, LAURA;COTTIGLIA, FILIPPO;CABONI, PIERLUIGI;FLORIS, COSTANTINO;
2010-01-01
Abstract
Chemical investigation of the stems of Seseli praecox (Gamisans) Gamisans, an endemic Apiaceae from Sardinia, afforded an isopropenylated chromone (5-hydroxy-6-(2-Z-butenyl-3-hydroxymethyl)-7-methoxy-2-methylchromone), along with four known linear furocoumarins and their natural precursor. For biological characterization the new compound was screened against four cancer cell lines in vitro and showed differential mu M antiproliferative effects between suspension and adherent cells.
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