Abstract Objective It is debated whether the Mood Disorder Questionnaire (MDQ) can generate false positives by screening other disorders as bipolar, or identify sub-threshold bipolarity. The aim is to verify if Quality of Life (QoL) impairment in MQD positives in the community is due to MDQ positivity itself, or to psychiatric diagnosis associated with MDQ positivity (supporting the former hypothesis). Method Community survey. Sample randomized after stratification of the adult population in the records of seven Italian regions. Tools: MDQ; Short Form Health Survey (SF-12); semi-structured clinical interview carried out by clinicians. Results Positives at MDQ show worsening QoL with an attributable burden of 2.8±1.8 lower than in MDD (5.6±3.6, p<0.001) or Eating Disorders (4.4±6.6, p<0.03) and similar to Panic Disorder (2.9±0.9, p=0.44). The burden is lower in the middle-aged (25-59 years) than in the young (18-24) (4.65±4.5 vs 2.58±2.0, p=0.007) or in the elderly (≥60) (4.12±3.2; p=0.024). In the elderly the burden is independent from comorbid psychiatric disorders. Limitations This is a preliminary study based on one survey not designed to test this specific hypothesis, thus its results have a heuristic value only. Conclusions The worsening of QoL due to positivity at MDQ is largely independent from comorbid conditions, supporting the hypothesis that MDQ positivity identifies a specific area of suffering that is "subthreshold" to the psychiatric diagnosis, and relevant for public health.

Does Mood Disorder Questionnaire identify sub-threshold bipolarity? Evidence studying worsening of quality of life

CARTA, MAURO;MORO, MARIA FRANCESCA;
2015

Abstract

Abstract Objective It is debated whether the Mood Disorder Questionnaire (MDQ) can generate false positives by screening other disorders as bipolar, or identify sub-threshold bipolarity. The aim is to verify if Quality of Life (QoL) impairment in MQD positives in the community is due to MDQ positivity itself, or to psychiatric diagnosis associated with MDQ positivity (supporting the former hypothesis). Method Community survey. Sample randomized after stratification of the adult population in the records of seven Italian regions. Tools: MDQ; Short Form Health Survey (SF-12); semi-structured clinical interview carried out by clinicians. Results Positives at MDQ show worsening QoL with an attributable burden of 2.8±1.8 lower than in MDD (5.6±3.6, p<0.001) or Eating Disorders (4.4±6.6, p<0.03) and similar to Panic Disorder (2.9±0.9, p=0.44). The burden is lower in the middle-aged (25-59 years) than in the young (18-24) (4.65±4.5 vs 2.58±2.0, p=0.007) or in the elderly (≥60) (4.12±3.2; p=0.024). In the elderly the burden is independent from comorbid psychiatric disorders. Limitations This is a preliminary study based on one survey not designed to test this specific hypothesis, thus its results have a heuristic value only. Conclusions The worsening of QoL due to positivity at MDQ is largely independent from comorbid conditions, supporting the hypothesis that MDQ positivity identifies a specific area of suffering that is "subthreshold" to the psychiatric diagnosis, and relevant for public health.
Bipolar disorders; Mood Disorder Questionnaire; Quality of life; Screening; Spectrum; Adult; Aged; Bipolar disorder; Early diagnosis; False positive reactions; Female; Humans; Italy; Male; Mass screening; Middle aged; Mood disorders; Quality of life; Surveys and questionnaires; Affect; Psychiatry and mental health; Clinical psychology; Medicine (all)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11584/176507
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